Science Forum

Science Forum

  1. SubscriberPonderable
    chemist
    Linkenheim
    Joined
    22 Apr '05
    Moves
    582047
    18 Jun '20 14:22
    https://phys.org/news/2020-06-smart-chemistry-anti-cancer-drugs-side.html

    The guys reseached what is Happening with doxorubicin in the Body and wehre the serious side effects come from, then they designed a better Version. Hopefuly it is approved soon.
  2. Subscribersonhouse
    Fast and Curious
    slatington, pa, usa
    Joined
    28 Dec '04
    Moves
    53125
    19 Jun '20 16:24
    @Ponderable
    Good news, and they may find even more variants with even less side effects.
    One question, if there are no DNA breaks and such, what is the mechanism that kills the cancer cells?
  3. Joined
    06 Mar '12
    Moves
    642
    19 Jun '20 19:493 edits
    @sonhouse said

    One question, if there are no DNA breaks and such, what is the mechanism that kills the cancer cells?
    That is sort of explained but in a confusing way in the OP link with;

    "...it also causes damage to chromatin, a kind of marbles inside the cell nucleus around which the DNA is wrapped..."

    but I find that a confusing assertion because it implies the DNA isn't part of the chromatin itself but, and as wiki says, the DNA IS part of the chromatin itself!
    https://en.wikipedia.org/wiki/Chromatin
    "Chromatin is a complex of DNA and protein ..."

    So perhaps what they meant to say but messed up the edit of it was just the protein part of the chromatin i.e. NOT the DNA part?
  4. SubscriberPonderable
    chemist
    Linkenheim
    Joined
    22 Apr '05
    Moves
    582047
    26 Jun '20 07:47
    So the original source is available:

    https://www.pnas.org/content/early/2020/06/16/1922072117

    The Point in Question is to Damage the Chromatin, which kills the cell. Of course the authors don't explain About Chromatin and the Science Journalist didn't enlighten us really.

    The Point in Question is that in earlier times it was thought that the Breaking of both DNA-starnds simultaniously was the key for the anti-Cancer activity. But it was found out that actually the Chromatin-dmahgae alone is sufficient and that activity seems to be restricted mainly to Cancer cells.
Back to Top