The Nimzovich Defence with 2.Nf3 arises after 1.e4 Nc6 2.Nf3. ECO code: B00.
White develops naturally. After 2...e5, the game transposes into standard Open Game territory (Ruy Lopez, Giuoco Piano, etc.). Black can also play 2...d6 (entering Pirc Defence-like structures) or 2...d5, challenging the centre directly.