The Sicilian Defence with 2.Nf3 arises after 1.e4 c5 2.Nf3. ECO code: B27.

The main move, preparing 3.d4 cxd4 4.Nxd4—the Open Sicilian. This is the starting point for approximately 80% of master-level Sicilian games. Black must now choose a specific defence: 2...d6 (leading to Najdorf, Dragon, Classical), 2...Nc6 (Sveshnikov, Accelerated Dragon, Taimanov), 2...e6 (Scheveningen, Kan, Taimanov), or other setups.