I've played it a few times - it's particularly nice against computers, which often underestimate the strength of the black position. Someone (Bronstein?) wrote that it's such a simple opening - you just give up a pawn and then get a really good game.
The only problem I see from a practical standpoint is that white has to play along, and it's not that hard to avoid it:
http://www.uschess.org/news/uschamp98/prelimA5/dgm1-0201.html
Also, a lot of us amateur d4 players are aiming for a Colle setup instead of c4, so you're not going to get to play it against them either...
If I were you I'd also look at Korchnoi's games against the Benko - he never lost against it (10 wins, 4 draws) until 1995 - (2-2 since then).
You can look them up using www.chessgames.com 's search function.
This Korchnoi-Topalov game is really interesting - Topalov shows you can win even with the queens off:
http://www.chessgames.com/perl/chessgame?gid=1143913
So go for it, but you won't get to play it every time your opponent plays d4.