Sounds like you're feeling the same frustration that most of us have had to deal with at one time or another. You put in some time studying an opening that looks promising and leads to positions that you like (and hopefully understand). You try to play the opening a few times and get ambushed by moves that you're not familiar with, don't like the position that you end up with, and maybe lose the game. This happens a lot. It's part of the learning curve that you navigate in order to establish an opening repertoire.
Don't give up and fall into the trap of believing that the problem is the opening. It's not (usually). Not if you're playing main lines, anyway. Thousands of books on "not quite mainstream openings" have been sold based on this thinking. Chances are you misplayed the position or missed a 1-2 move tactical shot and things didn't work out for you.
There's no universal opening scheme that will always lead to positions that you're comfortable with. Class players don't need to invest huge amounts of time studying openings, but they should have a repertoire they have confidence in. This takes time to acquire. If you switch openings looking for that magic system of play, you'll keep getting frustrated, and years later you still won't have an opening repertoire.
If you've chosen main line openings, you have a good start. Titled players use these openings when the money and their reputations are on the line for a reason. They are the best opening moves humans and machines have been able to devise. They work. If you get tripped up in a few games, analyze and figure out where you went wrong. Chessplaying friends, databases, and opening books can all help with this. Post games on this forum and ask for help. Every time you determine where you went wrong in a game, you add a bit to your knowledge base. Don't memorize. Understand what went wrong and how you could have improved on your play.