As white, I play 1. e4 and then:
- Tarrach variation against the French (3. Nd2),
- Open Sicillian against c5 (Yugoslav against the Dragon and as Yugoslav-like against other Sicillian variants as I can)
- Italian or Spanish against e5. I'm more comfortable in the Italian, but I'm beginning to see that 3. Bb5 is slightly better
- against other defenses, I basically just put the pawns on e4 and d4, the knights on f3 and c3 and then decide what to do with the bishops based on where the other guy's pieces are
As black, I play the open Sicillian/Dragon against e4 and against closed Sicillian openings I still fianchetto the dark bishop and play d6, even if that's not officially called the Dragon.
Against c4 or d4 I usually play the KID, though I'm toying with switching to the Dutch Leningrad (in honor of Henrik Danielson a/k/a Krakkaskak a/k/a the Polar Bear) and because in the KID you're gonna try to put the pawn on f5 eventually anyway, so why not do it while the knight is still minding its own business on g8? I also tried the Benko recently once after I watched a Josh Waitzkin video about a Benko game, with some success (
Game 5953349). But, I don't really feel comfortable enough to try it against strong players yet.