In general, I think its about the same as regular chess. You still get a development lead and can still stake a position in the center of the board better than black.
One noticable difference is that, since the pieces tend to be less optimally placed and you're less familiar with the positions, its harder to get traps in the early part of the opening. There are a few positions where the h or a pawns hang if you're not paying attention though, every once in a while a bishop check or a knight is easier than you're used to. None of this has a real effect on white's advantage, but it might have some effect on some players effectiveness in the opening.