They need to get a better offensive coordinator. They definitly need 2 new WRs and a more dependable QB. I'd say try to get Anderson from Cleveland, I'm not sure how long he'll be there with Quinn. Revamp the D with a better secondary as they have a good run stop. I think they have a good halfback, perhaps need a better O-line to help him.
But - you'd do better to support the Rams in their INJURY CRISIS.
The only thing they need to specifically do with the top 5 pick is to trade it for a slightly lower pick, and work for O-Lineman. Use that trade to get a high-flying cornerback or safety. Then use the 2 and 3 pick, and the free agency to further bolster the defense and O-Line. With that you have a 10-6 or better team barring further bad luck: You'd have a near-perfect offense, St. Louis, if ya could JUST GET A SOLID O-LINE. I think it's been swapped up 4 times or 5 times this year.
SB '09 here We COME!!!!!!! *I graduate HS that year as well, so it is DESTINED.