Nikola Spiridonov (born 27 December 1938) is an International Grandmaster (1979) of chess from Bulgaria. He earned the FIDE Master (1975) and the International Master titles (1976). Spiridonov won the Bulgarian Championship in 1969 and 1971, while coming in second four times between 1959 and 1975. He had also shared first place at the Vidin 1974-75 tournament.
He is not to be confused with the better known Grandmaster Nikolai Spiridonov (1958 — 2006).