it seems to me that the following will happen positionally: White will have more space, but the pawn will be extremely over stretched this early on. Black would probably play Nc6 quickly, preventing a quick d4, all the while trying to work on that lonely e pawn. Because the knight is on f3, the f pawn cant help.
Random, unanalyzed though: If white played 2. e5, then 3.f4, 4. Nf3, then things might be different, but I haven't put any thought into it, so don't flame me.
In the March 2005 issue of Chess Life, the subject of GM Susan Polgar's column Opening Secrets is the line 1.e4 c5 2.Nf3 d6 3.Nc3 Nf6 4.e5. Her conclusion was that Black can equalize with proper play, but that some natural looking (but incorrect) lines could put Black in some difficulties.