24 Jan '14 18:49>1 edit
http://medicalxpress.com/news/2014-01-year-old-dog-cancer-reveals-secrets.html
"...This cancer, which causes grotesque genital tumours in dogs around the world, first arose in a single dog that lived about 11,000 years ago. The cancer survived after the death of this dog by the transfer of its cancer cells to other dogs during mating.
The genome of this 11,000-year-old cancer carries about two million mutations – many more mutations than are found in most human cancers, the majority of which have between 1,000 and 5,000 mutations. The team used one type of mutation, known to accumulate steadily over time as a "molecular clock", to estimate that the cancer first arose 11,000 years ago.
..."
Just a thought: if this cancer were to keep evolving for, say, the next 10 million years like it has been evolving for the last few thousand years, it may mutate so much and become so different that, if we didn't have the benefit of hindsight, we would think it wasn't cancer at all but is a single-celled disease-causing parasite completely unrelated to cancer or dog cells and which evolved from another singled-celled organism, not a dog cell!
This makes me wonder if there are some other species of single-celled disease-causing parasites living today that we wrongly naturally assume evolved from other singled-celled organisms unrelated to their host's cells when, in fact, they evolved from infectious cancer cells of their hosts?
"...This cancer, which causes grotesque genital tumours in dogs around the world, first arose in a single dog that lived about 11,000 years ago. The cancer survived after the death of this dog by the transfer of its cancer cells to other dogs during mating.
The genome of this 11,000-year-old cancer carries about two million mutations – many more mutations than are found in most human cancers, the majority of which have between 1,000 and 5,000 mutations. The team used one type of mutation, known to accumulate steadily over time as a "molecular clock", to estimate that the cancer first arose 11,000 years ago.
..."
Just a thought: if this cancer were to keep evolving for, say, the next 10 million years like it has been evolving for the last few thousand years, it may mutate so much and become so different that, if we didn't have the benefit of hindsight, we would think it wasn't cancer at all but is a single-celled disease-causing parasite completely unrelated to cancer or dog cells and which evolved from another singled-celled organism, not a dog cell!
This makes me wonder if there are some other species of single-celled disease-causing parasites living today that we wrongly naturally assume evolved from other singled-celled organisms unrelated to their host's cells when, in fact, they evolved from infectious cancer cells of their hosts?