https://www.sciencemag.org/news/2021/01/sloppy-science-or-groundbreaking-idea-theory-how-cells-organize-contents-divides
"Many researchers are now convinced that phase separation explains many aspects of cell organization and function. Several research groups have reported that the mechanism helps convene the hundreds of proteins that carry out transcription, the process of reading DNA to produce the RNA instructions for making proteins. Similar molecular corralling may underlie functions including memory in fruit flies, immune cells’ responses to pathogens, DNA silencing, transmission of nerve impulses across synapses, and reproduction of SARS-CoV-2, the pandemic coronavirus."
This is an easy to read lay article on the ongoing controversy in phase separation as a explanation for cellular organization. It seems lots of scientists are convinced, but we don't really have great tools to discern phase separation from other mechanisms. Any thoughts on this?