Originally posted by googlefudge
Thalidomide was thought to be without side effects until they started prescribing it.
This sounds like very interesting research... but there is an awful lot of testing and
research needed between where they are and an actual drug on the market.
And no guarantee that it will actually pan out.
I'll get excited when they have promising results from stage 3 drug trials.
I understand your caution. We have many times heard of very promising sounding cancer research into a new cancer drugs for many years only for the drug to become proven to be no where near as good as we hoped. But that was always because the new drug proved not to be as selective against cancer as we hoped. Often the reason for this is because the drag's anti-cancer effect was either discovered by accident or by trial and error and, in either case, we didn't have a clear understanding of how it worked which means we only assumed good selectivity against cancer by the crude initial empirical data alone when we had never had any special reason to believe it was totally selective thus giving no side effects. You just mentioned Thalidomide but that is a good example of that:
"...The exact way this drug works against cancer cells is not clear. ..."
-therefore we never did have a good reason to believe that it is so selective that it had a good chance to give no side effects.
But what is being proposed in the OP is fundamentally different because what they are proposing is making designer drags which are so designed that we DO know exactly how they work and, more critically, because they are cleverly designed so to supposed to have total
complete selectivity, we HAVE a good reason to believe they have a good chance of being totally selective and with no side effects.
So, although I would still be cautiously
optimistic, I still believe this is very promising line of research indeed (and the most promising one to date ) that could lead to fantastically effective drugs against cancer and without the nasty side effects.