While we are talking about the Caro, when I still played 1.e4 I used to play the Panov attack vrs the caro-kahn
1.e4 c6
2.d4 d5
3. exd5 cxd5
4. c4
A very stong club player claims that this is refuted by 4... e5. Personally I don't see it though. My database contains 2005 games of Topalov playing the Panov attack, so it's hard to consider that anything but a joke, but how would you all continue against 4... e5? The chessbase big database contined 2 games with that position, both from 1960 or earlier.
I had a brief look at it when I was considering playing e4 as well as d4. It has an advantage of being light on theory, although admittedly black can equalise with accurate play (it does hold a trap or two, however). Of course, with it being a rare opening, white could also have an advantage of being more familiar with the positions and formations arising from the opening.
Qf3 doesn't appear to offer much. Addmitedly it's not the easiest thing to attack the white queen, but not impossible either. Personally as I don't understand the idea I wouldn't play it.
I have never lost against the Caro-Kann, it makes it so easy for White. There is rarely anything to fear except that you will blunder it all away. However, I only played 4 Caro-Kann games and they were all against players