10 Apr '20 11:52>1 edit
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@eladar saidLooks like the large number of darker skinned people who are being killed in places far north of the equatorial region is in part natural selection.
https://www.britannica.com/topic/race-human/Race-and-the-reality-of-human-physical-variation
Melanin, a substance that makes the skin dark, has been shown to confer protection from sunburn and skin cancers in those very areas where ultraviolet sunlight is strongest. Dark skin, which tends to be thicker than light skin, may have other protective functions in tropical environ ...[text shortened]... oss of melanin in favour of skin tones that enabled some individuals to better synthesize vitamin D.
The post that was quoted here has been removedThere are poor white people too. Most people that get SARS2 do not need to go to the hospital.
@metal-brain saidDo you have a reliable reference for this statement? My understanding, which can be totally wrong, is that it's expressed in all humans. What I'm wondering is how conserved the enzyme is. If there's more than one variant the virus might bind more strongly to some people's ACE2 protein than others. If this can be tested for it'll help health service staff, as they can be put on covid-19 wards and non-covid-19 wards depending on their genetic susceptibility. It also tells us what order to vaccinate people in if and when a vaccine is available.
There are poor white people too. Most people that get SARS2 do not need to go to the hospital.
It isn't because of a lack of access to healthcare. You are wrong about that. Quality is not enough to explain the high numbers/population ratio. We already know that ACE2 receptors are more common in Asian men. SARS2 does not kill races or gender equally. The sooner you acc ...[text shortened]... open discussion about SARS killing more of certain races than others. You are in denial of reality.
Although real-time PCR revealed that ACE2 mRNA expression is present in 72 human tissues [8], ACE2 protein expression has thus far been identiļ¬ed only in heart, kidney, and testis [1].
@deepthought saidhttps://www.nature.com/articles/s41421-020-0147-1
Do you have a reliable reference for this statement? My understanding, which can be totally wrong, is that it's expressed in all humans. What I'm wondering is how conserved the enzyme is. If there's more than one variant the virus might bind more strongly to some people's ACE2 protein than others. If this can be tested for it'll help health service staff, as they can ...[text shortened]... ps://onlinelibrary.wiley.com/doi/epdf/10.1002/path.1570
[2] https://www.ncbi.nlm.nih.gov/gene/59272
@metal-brain saidThanks, I think they're talking about gene variation rather than absence in non-Asians, but I've been drinking and need to leave reading it properly 'till tomorrow. Lock down alcoholism...
https://www.nature.com/articles/s41421-020-0147-1
@deepthought saidReference [2] just says that a particular gene causes the production of the ACE2 protein which coronavirus sticks to. It also describes the biochemical properties of that protein.
Do you have a reliable reference for this statement? My understanding, which can be totally wrong, is that it's expressed in all humans. What I'm wondering is how conserved the enzyme is. If there's more than one variant the virus might bind more strongly to some people's ACE2 protein than others. If this can be tested for it'll help health service staff, as they can ...[text shortened]... ps://onlinelibrary.wiley.com/doi/epdf/10.1002/path.1570
[2] https://www.ncbi.nlm.nih.gov/gene/59272
@athousandyoung saidThe nature article that @metal-brain linked a couple of posts ago does answer the question. There is variation in the ACE2 protein and given data from ICNARC where the rate of admittance for Covid-19 was significantly higher for non-whites than for white people compared with non-covid-19 pneumonia seems to indicate that variation in this gene makes people more or less susceptible to the virus. One would expect socio-economic factors to be as important for non-covid-19 viral pneumonia so I think this is a real effect.
Reference [2] just says that a particular gene causes the production of the ACE2 protein which coronavirus sticks to. It also describes the biochemical properties of that protein.