Originally posted by @wildgrass
Do you think the pharmaceutical "work-arounds" to the benefits of calorie restriction (for example, resveratrol) will ever work,
well, it certainly couldn't work for resveratrol because I am afraid that is all just one big myth and I would say almost as bad as the 'cold fusion' nonsense.
"...Boffins debunk red wine miracle antioxidant myth
Soz winos: no positive effects from resveratrol, scientists soberly conclude..."
there is no good evidence that consuming resveratrol affects life expectancy or human health
There is no evidence of benefit from resveratrol in those who already have heart disease.
There is no conclusive evidence for an effect of resveratrol on human metabolism
There is no evidence for an effect of resveratrol on lifespan in humans
In 2010, GlaxoSmithKline suspended a small clinical trial of SRT501, a proprietary form of resveratrol, due to safety concerns, and terminated the study later that year. SRT501 was composed of microparticles (< 5 µm) intended to enhance absorption and was delivered at a dose of 5 grams per day, causing gastrointestinal disorders and diarrhea in many subjects. Although limited human studies have shown resveratrol is well-tolerated, one clinical study of Alzheimer's disease patients showed there were side effects from daily intake of up to 2 grams, including nausea, diarrhea, and weight loss
But this health myth has been pounced on by advertisers who make it out to be fact conning god knows how many millions of people into buying what is at best a complete waste of money. Perhaps, in a way, that makes it actually worse than the 'cold fusion' nonsense.
I would also make the educated guess that there is no 'simple' work-around in chemical form that would give the same benefits as of calorie restriction, at least not without significant harmful side effects, else, if there is such a 'simple' chemical work-around, that would beg the question of why didn't we evolve enzymes in our body to make that beneficial chemical to prolong our natural lives without any significant biological cost and thus, obviously, increase our chances of passing on our genes? That is, after all, what you should expect evolution to do.