@Metal-Brain
In a rocket, there would be antimatter stored in a magnetic trap and and then a plasma generator of ordinary matter, the two types of matter would have a controlled stream of each one on separate paths and coming together in a rocket chamber, and THERE is where the reaction would take place, and the heat from that reaction would accelerate a third stream of ions, maybe hydrogen ions, basically a stream of protons, which would be heated to a tremendous degree, much higher temperature than ANY other kind of rocket and therefore a much higher ISP rate with much higher propellant velocity which obeys kinetic energy laws and therefore you get much better thrust for the weight of the propellant that any other craft would have kg for kg of propellant mass.
There is no danger of an explosion because the anti matter has its own stream and it has just enough energy to zap the hell out of a propellant, maybe it would be Argon but there is much higher exhaust velocity for lighter ions so they would probably use hydrogen.
They could use water after the H and O are separated
probably by electrolysis and ionized, (neutral ions would not react to the magnetic field) the H would have one path in a magnetic field and because Oxygen is much heavier than Hydrogen, they could be run together in a mixed stream and meeting the curved magnetic field the Hydrogen would bend at a much sharper angle than oxygen so they would be on separate paths exiting the steering magnet.
That is exactly how one of the clean room machines works, ion implanters which I was field maintenance for near 20 years so I know exactly what I am talking about in the case of the steering magnet, which means the O2 can be sent to its own chamber and the H to meet up with the antimatter stream but where they meet there is not enough actual mass to make any kind of explosion, just a controlled release of a LOT of energy, some ten times that of the next competitor, fission and thousands of times the energy involved in ANY chemical rocket.
Of course a craft like that would be built in space and supplied kind of like the ISS during construction and then loaded with fuel, supplies and then people after non human tests are run and confirmed ok then human test flights would proceed.
If the engineering is done right that vehicle could get to over half the speed of light, maybe 90% so a trip to Alpha Centauri could be completed one way in maybe 8 to 6 years and of course the closer to c you get, the less time the crew thinks it took so they will age less than say a twin on Earth, if they went far enough, they might age 20 years but the twin could be long dead by the time they get back to Earth and probably nobody would have even known about your existence after 200 years but that is another story.
I hope you actually read this, it should give you an idea of how safe such a vehicle would be, much safer than a fission rocket because there would be no onboard fission material with those attendant problems, radiation direct to the crew and such and the weight of the fission fuel and the weight of the propellant would ALL be much higher to get to say Alpha Centauri.
I like Alpha Centauri as a first place to travel when you can get 90+% of c because it is a triple star system so you get to visit three stars for the price of one major journey, the three stars are less than a tenth of a LY apart so that would be a snap for our intrepid explorers and astronomers have already detected one planet in the goldilocks zone around one of the dwarf stars in that triple system so that is where I would place my bets as to first trip into interstellar space.